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Although drug related acute kidney injury is commonly associated with the use of individual classes of drugs (such as antiretroviral drugs, aminoglycoside antibiotics, and non steroidal anti inflammatory drugs (NSAIDs)),9 10 11 12 13 little is known about the effects of drug drug interactions on this outcome. This aspect is particularly relevant among users of antihypertensive drugs, who often need more than one drug for adequate blood pressure control. For example, in patients with heart failure and hypertension, the concurrent use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers along with diuretics is common.14 15 16 However, many of these patients also have chronic inflammatory diseases or chronic pain, so the add on use of NSAIDs may be indicated.
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